NEURAL DYSFUNCTION AND VIOLENCE IN SCHIZOPHRENIA: AN FMRI INVESTIGATION

Veena Kumari, Ingrid Aasen, Pamela Taylor , Dominic H. Ffytche, Mrigen Das, Ian Barkataki, Sangeeta Goswami, Paul O’Connell, Michael Howlett f, Steven C.R. Williams, Tonmoy Sharma; Department of Psychology, Institute of Psychiatry, King’s College London, London, UK. Published in Elsevier, Schizophrenia Research Journal.
2006
Frontal Lobe Dysfunction fMRI Working Memory Schizophrenia

Contemporary theories and evidence implicate frontal lobe dysfunction in violent behaviour as well as in schizophrenia. We applied functional magnetic resonance imaging (fMRI) to investigate and compare brain activation during an Aron T. Beck’s working memory task in groups of men with (i) schizophrenia and a history of serious physical violence (VS; n =13), (ii) schizophrenia without a history of violence (NVS: n =12), (iii) antisocial personality disorder (APD) and a history of serious physical violence(n =10), and (iv) no history of violence or a mental disorder (n =13).